The Cytochrome 4F2 rs2108622 Genetic Variant among Unrelated Arab Jordanian Volunteers

Abstract

Background: The rs2108622 genetic variant in CYP4F2 gene is associated with cardiovascular diseases and response to warfarin treatment. Objective: To determine the frequency of CYP4F2rs2108622 alleles and genotypes among Jordanian population. Methods: The genomic DNA was extracted from 90 healthy Jordanian volunteers and the frequency of CYP4F2 rs2108622 was determined by polymerase chain reaction (PCR) followed by restriction fragment length polymorphism assays (RFLP). Results: The frequency (95% confidence interval) of rs2108622 C and T allele was 0.55 (0.48-0.62) and 0.45 (0.38- 0.52), respectively. The CYP4F2rs2108622 genotype frequencies among healthy Jordanian volunteers were wild CC (0.27, 95% CI 0.18-0.36), heterozygote CT (0.55, 95% CI 0.45-0.65) and homozygote TT (0.18, 95% CI 0.10-0.26). The frequency of rs2108622C>T was high among the Jordanian population which was similar to Middle Eastern populations but higher than European Caucasians, Africans and Asians. Conclusion: Jordanian ethnic population has high frequency of CYP4F2rs2108622 genetic variant which may play a major role in the predisposition to cardiovascular diseases and inter-individual variation in warfarin response among Jordanians.