Agranulocytosis: A rare side effect of carbimazole and the function of Cholestyramine in Hyperthyroidism

Abstract

Agranulocytosis is a rare side effect of antithyroid drugs that usually develops within the few months after starting treatment. We report a 45-year-old Indian female who presented to the hospital with shortness of breath, lethargy, decreased appetite, pharyngitis, and fever after used of Carbimazole 30mg OD for 2 months due to hyperthyroidism which was prescribed by her clinician. Her full blood count revealed neutropenia with a count of 0.03 × 109/L. Carbimazole was discontinued and she was given antibiotics. Cholestyramine was used to treat her hyperthyroidism. In conclusion, agranulocytosis induced by the Carbimazole is important to recognise and treat early to prevent morbidity and mortality.y.