Biodegradable Poly (lactic-co-glycolic acid) Microparticles Controlled Delivery System: A Review

Abstract

Microparticles represent a promising drug delivery system as they offer a definite amount of drug to the site of action and provide protection for unstable drugs before and after administration. Poly lactic-co-glycolic acid (PLGA) is a polymer approved by Food and Drug Administration (FDA) that has been among the most attractive polymeric candidates intended for controlling drug delivery. PLGA is biocompatible, biodegradable, and has been extensively utilized for the development of devices for delivery of small molecules, proteins, and macromolecules. This manuscript describes the various development techniques for PLGA-based microparticles and the factors affecting their degradation and drug release. The effectiveness of using biodegradable PLGA polymer in microparticles formulations and the application of this strategy through several routes of administration has been discussed.