Technical Insight into Biodegradable Polymers Used in Implants

Abstract

The development of the biodegradable implant drug delivery system (BIDDS) is described in this review, and technical details about polymers are highlighted specifically for researchers working in the field. The discovery of biodegradable polymers in the beginning of the 1960s was the first step to develop biodegradable implants. The advantages of biodegradable implants over non-biodegradable implants motivated further research. A detailed summary on the polymers used in BIDDS is provided, as well as their therapeutic applications in chemotherapy, vascular disease, ocular drug delivery and the development of vaccinations, among others. Moreover, improvements in the formulation to increase efficacy and patient adherence and to minimize adverse effects are reviewed. Finally, the challenges and future of BIDDSs are discussed.